Sargassum horneri as a Prebiotic Dietary Supplement for Immunity Development in Streptococcus parauberis Infected Zebrafish Model

Sargassum horneri (SH) is a brown macroalgal species commonly found along the coast of Japan, China, and Korea. SH possesses valuable bioactive compounds that can be developed as functional food ingredients well pharmaceutical agents for both humans animals. In this study, was tested its potential prebiotic effect. Several solvent-assisted extracts were on growth three probiotics (LAB) (Lactobacillus plantarum, Lactobacillus pentosus, brevis ) fish pathogen bacteria ( Streptococcus iniae, parauberis, Edwersiella tarda in vitro vivo . According to results, Celluclast extract (SHC) crude polysaccharide (SHCPs) showed outstanding enhancing activity all LAB excellent antibacterial against pathogenic dose-dependently. Both SHC SHCPs induced production secondary metabolites from LAB. The successfully reduced bacterial growth. Furthermore, experiments revealed co-treatment with SHC/SHCPs diminished mortality parauberis infected zebrafish by modulating iNOS, COX-2 expressions. Similarly, act an anti-inflammatory agent S. infection hindering NF-κB pathway activation. Conclusively, results achieved study suggest has used dietary supplement protective effect infections aquaculture industry.